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Aldactone (spironolactone) is an aldosterone receptor antagonist that causes the kidneys to remove water and sodium from the body, with reduced losses of potassium. Aldactone is used to reduce edema caused by heart, liver or kidney problems, hypertension, and certain patients with hyperaldosteronism.
Mechanism Of Action. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
Hormonal changes. Adrenal gland insufficiency (Addison's disease) affects your adrenal glands' ability to produce hormones that help maintain your body's balance of sodium, potassium and water. Low levels of thyroid hormone also can cause a low blood-sodium level.
Spironolactone tablets belong to a group of medicines called potassium-sparing diuretics (water tablets), which help you lose excess fluid from your body. They may be used for: congestive heart failure. nephrotic syndrome (a kidney disorder)
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