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No, you should not drink alcohol when taking the medication Plavix (also known as clopidogrel bisulfate). Alcohol can increase your risk of bleeding, especially in your stomach or intestines, and can make the potential side effects of Plavix worse (bruising, bleeding that won't stop).
It takes 5.5 x half-lifes of a medicine for it to be out of one's system. So Plavix should be cleared from your system in about 5.5 x 6 hours = 33 hours.
Plavix is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels. Plavix may also be used for purposes not listed in this medication guide.
CYP1A2, CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5 are implicated as cytochrome P450 enzymes involved in the metabolism of clopidogrel. However, the relative importance of the individual enzymes and which part of the reaction they are involved in are controversial, as discussed in the literature.
Both medications can increase the chance that the patient may have bleeding issues. Therefore the potential that Plavix and ibuprofen (And other NSAIDs) taken together can increase the risk of severe bleeding to dangerous levels means that these two drugs should usually not be taken together.
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