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Metabolism And Excretion. Clozapine is almost completely metabolized prior to excretion, and only trace amounts of unchanged drug are detected in the urine and feces. Clozapine is a substrate for many cytochrome P450 isozymes, in particular CYP1A2, CYP2D6, and CYP3A4.
It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Clozapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include: Hallucinations - imagined voices or images that seem real.
Clozaril is used in the treatment of schizophrenia and belongs to the drug class atypical antipsychotics. There is no proven risk in humans during pregnancy. Clozaril 100 mg is not a controlled substance under the Controlled Substance Act (CSA).
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