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The 2 active ingredients in Diclegis that reduce nausea and vomiting in pregnancy—doxylamine succinate and pyridoxine hydrochloride, or vitamin B6—have been recommended as a first-line pharmacotherapy by American College of Obstetricians and Gynecologists guidelines for the past 9 years.
If you still had nausea and vomiting on Day 3, start taking 4 tablets each day (1 tablet in the morning, 1 tablet in the afternoon, and 2 tablets at bedtime). Do not take more than 4 tablets (1 in the morning, 1 in the mid-afternoon, and 2 at bedtime) in 1 day. Take Diclegis on an empty stomach with a glass of water.
The big difference between the OTC option and Diclegis is price. You can buy 100 doxylamine 25 mg tablets for $12.79 and 100 vitamin B6 tablets 25 mg for $7.29. Diclegis is $345 for 60 tablets. The dose is two tablets a day, but some women need four tablets so the cost could be $690 a month (with a discount coupon!)
Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Pyridoxine is a form of vitamin B (B6). Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning sickness.
Yes. Doxylamine succinate-pyridoxine hydrochloride is well studied in its use to treat NVP. Studies totaling hundreds of thousands of exposed pregnant women have not found its use during pregnancy to increase the chance of birth defects or other adverse pregnancy outcomes.
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