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Methazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in the body. Methazolamide reduces the activity of this protein. Methazolamide is used to treat glaucoma.
The half-life of acetazolamide is between 10 to 15 hours. As an estimate it usually takes around 5 to 6 half lives for a drug to be eliminated from your system.
Studies have shown that prophylactic administration of acetazolamide at a dose of 250mg every eight to twelve hours before and during rapid ascent to altitude results in fewer and/or less severe symptoms (such as headache, nausea, shortness of breath, dizziness, drowsiness, and fatigue) of acute mountain sickness (AMS) ...
Carbonic Anhydrase inhibitors cause acidosis by preventing bicarb reabsorption. They cause hypokalemia by increasing the tubular flow, thereby maintaining a K+ excretion gradient and minimizing the ability to reabsorb it. ... Hyperkalemia is caused by the potassium-sparing diuretics.
Acetazolamide (Brand Name: Diamox) is a "water pill" (diuretic) used to prevent and reduce the symptoms of altitude sickness. Acetazolamide is also used with other medications to treat a certain type of eye problem (open-angle glaucoma). Acetazolamide is available in generic form.
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