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tramadol for depression. Tramadol is a synthetic opiate with seratonin and norepenephrine reuptake blocking properties (kind of like the SSRIs). However, because it is an opiate and thus has a high abuse potential, it is not perscribed to treat depression.
Stop using tramadol and call your doctor at once if you have any of these serious side effects: agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; seizure (convulsions); a red, blistering, peeling skin rash; or.
Give tramadol exactly as it was prescribed for your pet. For pain relief, the usual dose in dogs is 0.45-1.8mg per pound of pet's weight given by mouth every 8-12 hours. For treating chronic cancer pain in dogs, the usual dose is 0.45-1.8mg per pound of pet's weight given by mouth every 6 hours.
Tramadol works by changing the way the brain and body perceive pain. Specifically, tramadol both inhibits serotonin and norepinephrine reuptake AND activates opiate receptors in the central nervous system to enhancing the inhibitory effects on pain transmission in the spinal cord.
Summary: Since chronic pain syndromes and depression simultaneously occur in many patients, it is likely that tramadol and an SSRI will be used together. However, concomitant use of these drugs is known to increase the risk for seizures and serotonin syndrome (see the figure below).
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