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Psychotic illness, in particular schizophrenia, is considered to be caused by overactivity of dopamine in the brain. Chlorpromazine blocks the receptors that dopamine acts on and this prevents the overactivity of dopamine in the brain. This helps to control psychotic illness.
Most metabolites are excreted in the urine as unconjugated or conjugated forms. The half-life of chlorpromazine is variable at approximately 30 hours. Indications: The management of psychotic disorders including manifestations of the manic phase of bipolar depressive disorder and severe behavioral problems in children.
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Chlorpromazine belongs to the class of medications known as phenothiazines. It is used to treat mania and disorders with psychosis, such as schizophrenia. It is also used to prevent and treat nausea and vomiting. Chlorpromazine works by affecting the balance of chemicals in the brain.
Perphenazine is an anti-psychotic medicine in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting.
