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When was Depakote introduced to the U.S.? Depakote has been marketed in the United States since 1983. Until it was approved for use in treating manic depression on June 1, 1995, it was used exclusively in the treatment of epilepsy.
When treating epilepsy and manic episodes associated with bipolar disorder: There is positive evidence of human fetal risk during pregnancy. When treating migraine: Not for use in pregnancy. Depakote 500 mg is not a controlled substance under the Controlled Substance Act (CSA).
Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications. Divalproex sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches.
Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. Divalproex sodium is thought to work by increasing the levels of a brain neurotransmitter called gamma-aminobutyric acid (GABA).
BRAND NAME: Depakote, Depakote ER, Depakote Sprinkle, Depakene, Depacon, Stavzor. DRUG CLASS AND MECHANISM: Valproic acid and its derivative, divalproex, are oral drugs that are used for the treatment of convulsions, migraines and bipolar disorder. ... Scientists do not know the mechanism of action of valproic acid.
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