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    It is used to decrease fluid retention (edema) caused by congestive heart failure, certain kidney or liver problems, and medications such as corticosteroids (e.g., prednisone) and estrogen. It is also used to lower high blood pressure. Hydrochlorothiazide works by making the body lose excess water and salt.
    Hydrochlorothiazide can be taken with or without food. In adults being treated for hypertension, the usual dose is 12.5 to 50 mg once daily. If the medicine has been prescribed for edema, most adults will take 25 to 100 mg once a day or in divided doses.
    Diuretics (water pills): The risk for sulfa-containing diuretic medications causing reactions in sulfa-allergic patients is low. Many diuretic medications, such as hydrochlorothiazide (HCTZ) and furosemide (Lasix) are sulfa-based, while ethacrynic acid (Edecrin) is not.
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