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Clozapine can cause severe neutropenia which is a reduction in the number of white blood cells (absolute neutrophil count or ANC) below 500/?L. Severe neutropenia can lead to serious infection and death. Patients should immediately report symptoms of infection such as fever, weakness, lethargy, or sore throat.
Schizophrenia is associated with an overactivity of dopamine in the brain, and this may be associated with the delusions and hallucinations that are a feature of this disease. Clozapine works by blocking the receptors in the brain that dopamine acts on.
It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Clozapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include: Hallucinations - imagined voices or images that seem real.
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