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Contraindications: Some medical conditions may interact with eplerenone. Tell your doctor or pharmacist if you have any medical conditions, especially if you are pregnant, planning to become pregnant, or are breast-feeding, if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement, if you have allergies to medicines, foods, or other substances, if you have kidney problems, diabetes, or protein in your urine and if you have a history of high blood potassium levels.
Missed dose: If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Possible side effect: This medicine may increase the amount of potassium in your blood. Check with your doctor right away if you are having abdominal or stomach pain; nausea or vomiting; nervousness; difficulty with breathing; irregular heartbeats; confusion; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
Overdose: Overdosing can result in several symptoms like slow heart beat, dizziness, weak pulse rate, feeling like losing consciousness, weakness in muscles etc. You may also suffer from severe side effects such as allergic reactions (rashes, itching, swelling in mouth/lips/tongue/throat, difficulty in breathing etc), pain in the chest, unusual vaginal bleeding, sore or enlarged breasts (if you are male), palpitation, persistent diarrhoea, vomiting or swelling in the feet or ankles. Contact your physician immediately if you have accidentally overdosed and are experiencing any of the above symptoms.
Drug interactions: The medications that may interact with Inspra are Lithium because the risk of its side effects may be increased by eplerenone; Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of eplerenone's side effects; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease eplerenone's effectiveness and increase the risk of high blood potassium levels and Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased.
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