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Time to peak plasma concentration is approximately one hour. Distribution – Although the plasma half life of spironolactone itself is short (1.3 hours) the half lives of the active metabolites are longer (ranging from 2.8 to 11.2 hours). Spironolactone is estimated to be 90% protein bound.
Spironolactone works by blocking the actions of a hormone in the body called aldosterone. This hormone is produced by glands found above the kidneys called the adrenal glands. Aldosterone acts in the kidneys, where it is involved in controlling the balance of salt and water in the body.
According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. ... However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia.
Spironolactone is usually well tolerated, but just as with any medication, side effects are possible. Common side effects include irregular menses, midcycle spotting, breast tenderness, and headaches. Very rarely, Spironolactone can cause a rash, liver, kidney or blood problems.
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