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    Hydrochlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).
    BRAND NAMES: Maxzide, Dyazide. DRUG CLASS AND MECHANISM: Triamterene/hydrochlorothiazide is an oral diuretic (water pill) that is used for treating high blood pressure (hypertension) and edema (water accumulation). It is a combination of two different diuretics.
    Diuretics (water pills): The risk for sulfa-containing diuretic medications causing reactions in sulfa-allergic patients is low. Many diuretic medications, such as hydrochlorothiazide (HCTZ) and furosemide (Lasix) are sulfa-based, while ethacrynic acid (Edecrin) is not.
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    It is used to decrease fluid retention (edema) caused by congestive heart failure, certain kidney or liver problems, and medications such as corticosteroids (e.g., prednisone) and estrogen. It is also used to lower high blood pressure. Hydrochlorothiazide works by making the body lose excess water and salt.
    Hypertension (treatment)—Spironolactone and hydrochlorothiazide, triamterene and hydrochlorothiazide, and amiloride and hydrochlorothiazide1 are also indicated in the treatment of hypertension, especially when a potassium-sparing diuretic effect is desired.
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    The plasma elimination half-life of hydrochlorothiazide has been reported to be 6 to 15 hours.
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