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Contraindications. Do not take Leukeran if you are allergic to chlorambucil or any ingredients of this medication, are pregnant or breastfeeding, or if you have had a full course of radiation or chemotherapy within the previous 4 weeks.
Precautions. Before taking Leukeran you should talk with your doctor if you have seizures, head injury, gout, kidney stones, blood disorders (anemia, neutropenia, thrombocytopenia). Avoid contact with people who have contagious infections. Do not have immunizations or vaccinations without the consent of your doctor.
Directions. Take Leukeran exactly as prescribed by your doctor. Take this medication by mouth. Drink plenty of fluids while taking this medication to prevent side effects. For chronic lymphocytic leukemia, the usual adult starting dose is 0.15 mg per kilogram body weight per day until the total white blood cell count reaches the desired range. 4 weeks after the first course of treatment, the medication may be restarted at a dose of 0.1 mg per kilogram body weight per day. For Hodgkin's disease, the usual dose is 0.2 mg per kilogram body weight per day for 4 to 8 weeks. For non-Hodgkin's lymphoma, the usual dose is 0.1 mg to 0.2 mg per kilogram body weight per day for 4 to 8 weeks initially.
Missed dose. Take the missed dose as soon as possible. Skip the missed dose if it is time for your next scheduled dose. Don't take extra medicine to make up the missed dose.
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