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Lovastatin comes as a tablet and an extended-release (long-acting) tablet to take by mouth. The regular tablet usually is taken once or twice a day with meals. The extended-release tablet usually is taken once a day at bedtime. Take lovastatin at around the same time(s) every day.
Given that cholesterol is biosynthesized in the early morning hours, the US Food and Drug Administration (FDA) has recommended evening administration for statins with shorter half-lives (lovastatin 2 hours, simvastatin < 5 hours, and fluvastatin < 3 hours).
Lovastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver.
These statins are best taken at night. Simvastatin (Zocor) is an example of a statin that works better if taken in the evening. Studies show that when simvastatin is taken at night, there's a greater reduction in LDL cholesterol than when it's taken in the morning. Lovastatin (Mevacor) should be taken with dinner.
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