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Glyburide is an oral diabetes medicine that helps control blood sugar levels. Glyburide is used to treat type 2 diabetes. This medication is not for treating type 1 diabetes.
Stop taking this medication and call your doctor at once if you have any of these serious side effects: nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); pale skin, confusion or weakness;
BRAND NAMES: Micronase, Diabeta, Glynase Prestab. DRUG CLASS AND MECHANISM: Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes.
The apparent elimination half-life of glyburide in oral dosage forms available in the United States ranges from 7 to 10 hours. Glipizide has a terminal elimination half-life of 2-7 hours. The effects of renal and hepatic disease on the pharmacokinetics of glyburide and glipizide have not been well studied.
Actions. Glyburide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established.
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