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Elimination. Mainly via hepatic metabolism; less than 1% excreted as unchanged drug. Approximately 73% of dose recovered in urine and 20% in feces. The mean terminal half-life for immediate-release is 6 h, for ER is 7 h, and for N-desalkyl quetiapine is 12 h.
How long does it take for Seroquel® to work? It may take at least 2 to 3 weeks in order to see some improvement in your symptoms. The full benefit of quetiapine may not be seen for at least 4-6 weeks. NAMI wishes to thank the College of Psychiatric and Neurological Pharmacists for producing this fact sheet.
Quetiapine extended-release tablets are also used along with other medications to treat depression. Quetiapine tablets may be used as part of a treatment program to treat bipolar disorder and schizophrenia in children and teenagers. Quetiapine is in a class of medications called atypical antipsychotics.
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Seroquel affects various neurotransmitters in the brain, in particular serotonin and dopamine. It acts as an antagonist and blocks the receptors for these neurotransmitters, which controls the flow of these chemicals through the brain. For example schizophrenia is associated with levels of high dopamine.