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BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for oral administration.
The mean serum half-lives of sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. However, patients with severely impaired renal function exhibit an increase in the half-lives of both components, requiring dosage regimen adjustment (see DOSAGE AND ADMINISTRATION section).
Bactrim has an elimination half life of 6 to 12 hours. It usually takes around 5 to 6 half lives for a drug to be completely eliminated from your system. Other factors also affect elimination (age, health, weight, metabolism) but you can expect that your husband should be free of bactrim after about three days
Take each dose with a full glass of water. Take sulfamethoxazole and trimethoprim with food or milk if it upsets your stomach. You may crush the tablets and put them in water or a soft food like applesauce or pudding if you cannot swallow them whole.
Signs and symptoms of Bactrim overdose include: Anorexia. Fluctuating pain in the abdomen. Nausea and vomiting. Dizziness. Headache. Drowsiness. Unconsciousness. Fever.
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