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Tenofovir disoproxil fumarate is a prodrug of tenofovir that inhibits the activity of HIV-1 reverse transcriptase and hepatitis B virus (HBV) reverse transcriptase by competing with deoxyadenosine 5?-triphosphate and by DNA chain termination after incorporation into DNA.
Lopinavir is a protease inhibitor. The amount of Lopinavir in the blood stream stays much higher if it is taken with a small amount of ritonavir, another protease inhibitor. See Fact Sheet 442 for more information on ritonavir. Kaletra is a combination of lopinavir and ritonavir in the same tablet.
Raltegravir (RAL, Isentress, formerly MK-0518) is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.
3TC belongs to a group of drugs called nucleoside analogues. 3TC interferes with an enzyme called reverse transcriptase (RT), which is used by HIV-infected cells to make new viruses. Since 3TC inhibits, or reduces, the activity of this enzyme, this drug causes HIV-infected cells to produce less HIV.
Adefovir is an antiviral medication. It works by preventing viral cells from multiplying in the body and infecting new liver cells. Adefovir is used to treat chronic hepatitis B in adults. This medicine will not cure hepatitis.
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