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Eighty-five percent of radiolabeled anastrozole was recovered in feces and urine. Hepatic metabolism accounts for approximately 85% of anastrozole elimination. Renal elimination accounts for approximately 10% of total clearance. The mean elimination half-life of anastrozole is 50 hours.
Anastrozole is also called Arimidex. It is a type of hormone therapy called an aromatase inhibitor. Anastrozole treats advanced breast cancer in women who have had their menopause.
This medication is also used to treat breast cancer in women whose breast cancer has worsened after taking tamoxifen (Nolvadex). Anastrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen the body makes.
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In postmenopausal women, aromatase, an enzyme found in liver, fat, muscle, and breast cancer cells, changes androgens into the hormone estrogen. ... ARIMIDEX is an aromatase inhibitor that works by blocking aromatase, lowering the amount of the potentially cancer-causing estrogen in the body.