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A: Weight gain is a rare side effect of Nexium, occurring in less than 1 percent of patients who take it. The other medications you listed do not appear to cause weight gain, according to their prescribing information. If you are noticing a sudden weight change, it is best to consult your physician.
When your LES (lower esophageal sphincter) relaxes, excess acids can flow up, or reflux, into your esophagus. This can create the painful sensation of heartburn. Prilosec OTC works by directly blocking many of the active stomach pumps that produce acid before they start. Prilosec OTC is a proton pump inhibitor (PPI).
The only active ingredient in Nexium is the exact same thing as the only active ingredient in omeprazole (Prilosec), a (now) generic drug made by the same company, which is over the counter and four to eight times cheaper.
Nexium is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).
Nexium is a proton pump inhibitor. It decreases the overall acidity in the stomach by shutting down some of the proton pumps. It is not an "anti-acid." Antacids work by coating the stomach and lowering the acidity of the stomach contents, due to their strong base properties.
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