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DRUG CLASS AND MECHANISM: Glucovance (glyburide/metformin) is a combination antidiabetic medication containing glyburide and metformin. Glucovance is used to improve blood glucose (sugar) control in adults with type 2 diabetes mellitus. Glyburide is a second generation oral sulfonylurea.
Less serious side effects may include: sneezing, runny nose, cough or other signs of a cold; headache, mild dizziness; or. mild dizziness; or. mild nausea or vomiting, diarrhea, upset stomach.
Glyburide and metformin combination can cause low blood sugar. However, it also can occur if you delay or miss a meal or snack, drink alcohol, exercise more than usual, cannot eat because of nausea or vomiting, take certain medicines, or take glyburide and metformin combination with another type of diabetes medicine.
A glyburide overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).
Glyburide belongs to a class of drugs called sulfonylureas, and metformin is in a class of drugs called biguanides. Glyburide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently.
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