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Nolvadex (tamoxifen citrate) is a nonsteroidal antiestrogen used to treat breast cancer that has spread to other parts of the body (metastatic breast cancer), to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients.
Selective estrogen receptor modulators (SERMs) bind to estrogen receptors, preventing estrogen from binding. Examples of SERMs approved by the FDA are tamoxifen (Nolvadex®), raloxifene (Evista®), and toremifene (Fareston®). Tamoxifen has been used for more than 30 years to treat hormone receptor-positive breast cancer.
What do hormone blockers do to get rid of breast cancer? The most common hormone therapy drug is Tamoxifen. It blocks the estrogen-shaped openings in the cells, preventing estrogen-fueled cancers from growing. Tamoxifen can be taken as a pill on a daily basis, up to five years after surgery.
Hormone therapy drugsFigure 5.7: Hormone therapies commonly used to treat early and locally advanced breast cancerDrug Brand name Used in pre- or postmenopausal women?Tamoxifen Nolvadex Pre- and postmenopausalAnastrozole Arimidex PostmenopausalLetrozole Femara Postmenopausal3 more rows
Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women.
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