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Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and rheumatoid arthritis. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.
Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. You must use the correct dose of methotrexate for your condition. Methotrexate is usually taken once or twice per week and not every day. Follow the directions on your prescription label.
Methotrexate can be taken with other medications – NSAIDS (Celebrex®, Vioxx®, ibuprofen, naproxen), prednisone, Enbrel, plaquenil. You should not take methotrexate while taking any medicine containing trimethoprim-sulfa (Bactrim®, Sulfatrim®, etc…).
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