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CYP1A2, CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5 are implicated as cytochrome P450 enzymes involved in the metabolism of clopidogrel. However, the relative importance of the individual enzymes and which part of the reaction they are involved in are controversial, as discussed in the literature.
Elimination. Following an oral dose of 14C-labeled clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over the 5 days post-dosing. After a single, oral dose of 75 mg, clopidogrel has a half-life of approximately 6 hours.
Get medical help right away if you have any of these symptoms: purplish spots (purpura) on your skin or in your mouth (mucous membrane) due to bleeding under the skin. yellowing of your skin or the whites of your eyes (jaundice) tiredness or weakness. pale-looking skin. fever. fast heart rate or shortness of breath. headache.
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It stops blood cells called platelets from clumping together and forming blood clots. Clopidogrel is also available without a brand name, ie as the generic medicine. Clopidogrel works by preventing a natural substance called adenosine diphosphate (ADP) from binding to its receptors on platelets.
