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Calcirol contains the active ingredient cholecalciferol, also known as vitamin D3. It is used for the treatment of vitamin D3 deficiency, rickets, osteomalacia and patients of kidney failure. Vitamin D3 is essential for the proper growth and development of the body.
Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1?-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.
Sunlight exposure is the primary source of vitamin D for most people. Solar ultraviolet-B radiation (UVB; wavelengths of 290 to 315 nanometers) stimulates the production of vitamin D3 from 7-dehydrocholesterol (7-DHC) in the epidermis of the skin (see Production in Skin) (1).
Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase, a mitochondrial oxygenase and an enzyme which catalyzes the hydroxylation of 25-hydroxycholecalciferol (calcifediol). The activity of the enzyme is stimulated by PTH.
Vitamin D2 is the form of D that is found in fortified foods like milk, juices or cereals, and D3 is the form that is synthesized by the skin when it's exposed to the sun or (ultraviolet light/UVB). D2 (ergocalciferol) can be found in some plants/fungus.
Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally.
Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone.
There has been much progress in our understanding of the metabolism of vitamin D. It is now clear that vitamin D3 can be produced in the skin or ingested in the diet. It accumulates very rapidly in the liver where it undergoes 25-hydroxylation, yielding 25-OH-D3, the major circulating metabolite of the vitamin.
Vitamin D helps the intestines absorb calcium. However, the vitamin D must first be activated or "turned on" by parathyroid hormone (PTH). Once activated, vitamin D acts to greatly increase the amount of calcium that the intestines can absorb from food, sometimes by as much as two to four times.
Follow your physician's instructions carefully. Calcitriol may be taken with food, milk or on an empty stomach. Swallow whole, do not crush or chew the pill.
Calcitriol is used in patients with kidney disease who can't make enough of the active form of Vitamin D. This medication is also used to prevent and treat certain types of calcium/phosphorus/parathyroid problems that can happen with long-term kidney dialysis or hypoparathyroidism.
Calciferol (ergocalciferol) is vitamin D2 used to treat hypoparathyroidism (decreased functioning of the parathyroid glands), and is also used to treat rickets (softening of the bones caused by vitamin D deficiency) or low levels of phosphate in the blood (hypophosphatemia). Calciferol is available in generic form.
Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase, a mitochondrial oxygenase and an enzyme which catalyzes the hydroxylation of 25-hydroxycholecalciferol (calcifediol). The activity of the enzyme is stimulated by PTH.
Stop using calcitriol and call your doctor at once if you have a serious side effect such as: weakness, headache, drowsiness; nausea, vomiting, stomach pain, constipation; loss of appetite; dry mouth, increased thirst; metallic taste in your mouth; urinating more than usual; fast, slow, or uneven heart rate;
It is used to manage low blood calcium levels in patients who are on chronic kidney dialysis. ... Osteocap is a form of vitamin D. It works by promoting proper absorption and use of calcium and phosphate by the body in normal bone development and maintenance.
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