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Chloramphenicol Chloramphenicol Inhibits translation (protein synthesis)Quinolones Nalidixic acid Inhibits DNA replication
Chloramphenicol is used to treat bacterial eye infections. It is also used to treat serious life-threatening bacterial infections such as typhoid fever when given orally or intravenously. It is an antibiotic, sometimes known as a broad spectrum antibiotic as is effective against a wide variety of bacteria.
Chloramphenicol is a bacteriostatic by inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit, preventing peptide bond formation.
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Chemical class Examples Mode of actionTetracyclines Tetracycline Inhibit translation (protein synthesis)Semisynthetic tetracycline Doxycycline Inhibit translation (protein synthesis)
Chloramphenicol Chloramphenicol Inhibits translation (protein synthesis)Quinolones Nalidixic acid Inhibits DNA replication
