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When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
Sinemet (Levodopa/Carbidopa) Levodopa (also called L-dopa) is the most commonly prescribed and most effective drug for controlling the symptoms of Parkinson's disease, particularly bradykinesia and rigidity. Levodopa is transported to the nerve cells in the brain that produce dopamine.
Carbidopa and levodopa can be taken with or without food. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole.
Patients with Lewy Body dementia or Parkinson's disease with dementia can have hallucinations regardless of the medications that they take, but sinemet can make the hallucinations more common and worse. That being said, the other Parkinson's medications are often more likely to cause hallucinations than sinemet.
This combination medication is used to treat symptoms of Parkinson's disease or Parkinson-like symptoms (such as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain.
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