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Prescription medications Metoclopramide (Reglan) Promethazine (Phenergan) Prochlorperazine (Compazine) Trimethobenzamide (Tigan) Ondansetron (Zofran)
Reglan (metoclopramide) increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines. Reglan is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.
Metoclopramide is also used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents.
Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. ... The effect of metoclopramide on motility is not dependent on intact vagal innervation, but it can be abolished by anticholinergic drugs.
Metoclopramide is used to relieve heartburn caused by gastroesophageal reflux disease (GERD). It's also used to treat symptoms of diabetic gastroparesis. (This is slow stomach emptying in people with diabetes). Symptoms include nausea, vomiting, heartburn, constantly feeling full after meals, and loss of appetite.
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