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Depakote is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications. Depakote is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches.
Take Depakote delayed-release tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Swallow Depakote delayed-release tablets whole. Do not break, crush, or chew before swallowing.
Depakote tablets contain the active ingredient valproate semisodium, which is is a type of medicine called a mood stabiliser. It is used to treat the psychiatric illness bipolar affective disorder, or manic depression.
Valproic acid is thought to increase the production and prevent the breakdown of GABA in the brain. ... It is not fully understood how valproic acid works as a mood stabiliser in bipolar disorder, but is thought to be to do with the increased activity of GABA in the brain.
When was Depakote introduced to the U.S.? Depakote has been marketed in the United States since 1983. Until it was approved for use in treating manic depression on June 1, 1995, it was used exclusively in the treatment of epilepsy.
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