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Ezetimibe /??z?t?m?b/ is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine.
It is associated with muscle cramps, stiffness and spasms. Rhabdomyolysis is serious because it can cause the breakdown of muscles, which can cause acute kidney failure and can ultimately be fatal. Patients who develop unexplained muscle pain while taking Zetia should consult with their doctor immediately.
Ezetimibe belongs to the group of medications known as cholesterol absorption inhibitors. It lowers cholesterol levels by decreasing the body's ability to absorb cholesterol from the digestive system. It is used in addition to exercise and a healthy diet to lower cholesterol levels for people with high cholesterol.
Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. Ezetimibe may be used alone or with other drugs (such as "statins" or fibrates). Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet.
Both ezetimibe and ezetimibe-glucuronide are eliminated from plasma with a half-life of approximately 22 hours for both ezetimibe and ezetimibeglucuronide. Plasma concentration-time profiles exhibit multiple peaks, suggesting enterohepatic recycling.
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