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    Possible side effects of Zofran: All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Constipation; drowsiness; headache; irritation at the site of injection; tiredness.
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    Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.
    Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
    Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. ... Using dry hands, remove the tablet and place it in your mouth. ... Do not swallow the tablet whole. ... Swallow several times as the tablet dissolves.
    BRAND NAME(S): Zofran. USES: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.
    Zofran is used in the treatment of nausea/vomiting; gastroenteritis; alcohol dependence; obsessive compulsive disorder; nausea/vomiting, chemotherapy induced (and more), and belongs to the drug class 5HT3 receptor antagonists. ... Zofran 8 mg is not a controlled substance under the Controlled Substance Act (CSA).
    Zofran ODT comes in 4- and 8-mg orally disintegrating tablets. Zofran also comes in liquid form. To treat or prevent nausea or vomiting, you'll usually take a tablet 30 minutes before chemotherapy, one or two hours before radiation therapy, and one hour before surgery.
    Zofran Overview - Patient Information: Side Effects. SIDE EFFECTS: Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. If these effects persist or worsen, notify your doctor promptly.
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    For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor.
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