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Methazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in the body. Methazolamide reduces the activity of this protein. Methazolamide is used to treat glaucoma.
Carbonic Anhydrase inhibitors cause acidosis by preventing bicarb reabsorption. They cause hypokalemia by increasing the tubular flow, thereby maintaining a K+ excretion gradient and minimizing the ability to reabsorb it. ... Hyperkalemia is caused by the potassium-sparing diuretics.
In other words if you took a dose at 9am Monday, it would take somewhere between 50 to 90 hours (2 to 4 days) for the dose to be eliminated from your system.
Studies have shown that prophylactic administration of acetazolamide at a dose of 250mg every eight to twelve hours before and during rapid ascent to altitude results in fewer and/or less severe symptoms (such as headache, nausea, shortness of breath, dizziness, drowsiness, and fatigue) of acute mountain sickness (AMS) ...
BRAND NAME: Bumex (discontinued brand) DRUG CLASS AND MECHANISM: Bumetanide is a potent diuretic (water pill) that causes a profound increase in urine output (diuresis) by preventing the kidney from retaining fluid.
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