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Several anticonvulsant medications are recognized as mood stabilizers to treat or prevent mood episodes in bipolar disorder. At first, anticonvulsants were prescribed only for people who did not respond to lithium. Today, they are often prescribed alone, with lithium, or with an antipsychotic drug to control mania.
Oxcarbazepine is a medication that is sometimes used in patients with bipolar disorder (also known as manic depression). It is approved for the treatment of partial seizures. Bipolar disorder involves episodes of depression and/or mania.
Metabolism and Excretion. Oxcarbazepine is rapidly reduced by cytosolic enzymes in the liver to its 10-monohydroxy metabolite, MHD, which is primarily responsible for the pharmacological effect of Trileptal. MHD is metabolized further by conjugation with glucuronic acid.
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The half-life of oxcarbazepine itself is 2 hours and that of MHD is 9 hours, thus requiring at least twice-daily dosing. Oxcarbazepine is rather quickly metabolized to mostly MHD in plasma, and MHD is poorly plasma-protein bound (only 40% bound).
Common side effects of lithium**Weight gain.**Drowsiness.**Tremor.**Weakness or fatigue.**Excessive thirst; increased urination.**Stomach pain.**Thyroid problems.**Memory and concentration problems.
