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Less serious side effects may include: headache; muscle pain; dry mouth; nausea; vomiting, stomach pain, loss of appetite; weight loss; feeling tired or irritable; anxiety, mood changes; or.pain, swelling, or irritation where the interferon injection was given.
In general, the generic preparations are less expensive than the brand drugs. As a rough estimate, a 12-week course of generic ribavirin is in the range of $550 to $850. Accordingly, the ribavirin component of a 48-week treatment course costs approximately $1100 to $1700.
Take Copegus exactly as prescribed by your doctor. Ribavirin is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. Take this medication by mouth, usually twice daily with food for 24 to 48 weeks. Swallow this medication whole. The daily dose is 800 mg to 1200 mg administered orally in two divided doses. The recommended dose for hepatitis C in HCV/HIV coinfected patients is 800 mg daily for a total of 48 weeks, regardless of genotype.
The wholesale acquisition cost (WAC) for sofosbuvir is $1,000 per 400 mg pill. Accordingly, the cost for the sofosbuvir component in a 12-week treatment course is $84,000 (and the total regimen cost is depends on the other medications used in combination with sofosbuvir).
It is therefore necessary to consider an earlier reduction in the ribavirin dose in such patients to prevent discontinuation of treatment because of anemia. ... However, because red blood cells lack dephosphorylation enzymes, ribavirin accumulates in cells and destroys the cells, causing hemolytic anemia.
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