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Faslodex (fulvestrant) is an anti-estrogen medication. It works by blocking the actions of estrogen in the body. Certain types of breast cancer use estrogen to grow and multiply in the body. Faslodex is used to treat some hormone-related breast cancer.
Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women. Femara is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years
In primary breast cancer, if letrozole is your only treatment it's usually taken for five years. If letrozole is given after five years of tamoxifen, it will usually be given for two to three years. However, clinical trials exploring the optimum length of time to take letrozole are ongoing.
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About 90% of radiolabeled letrozole is recovered in urine. Letrozole's terminal elimination half-life is about 2 days and steady-state plasma concentration after daily 2.5 mg dosing is reached in 2-6 weeks.