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Reglan (metoclopramide) is a dopamine antagonist that is used as an antiemetic (anti-vomiting) agent used to treat nausea, vomiting, loss of appetite, heartburn and early satiety (feeling of fullness).
Metoclopramide increases muscle contractions in the upper digestive tract. ... Metoclopramide is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.
This medication is used to treat certain conditions of the stomach and intestines. ... Treating gastroparesis can decrease symptoms of nausea, vomiting, and stomach/abdominal fullness. Metoclopramide works by blocking a natural substance (dopamine). It speeds up stomach emptying and movement of the upper intestines.
Less serious metoclopramide side effects may include: feeling restless, drowsy, tired, or dizzy; headache, sleep problems (insomnia); nausea, vomiting, diarrhea; breast tenderness or swelling; changes in your menstrual periods; or. urinating more than usual.
The antiemetic action of metoclopramide is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone in the central nervous system — this action prevents nausea and vomiting triggered by most stimuli. At higher doses, 5-HT3 antagonist activity may also contribute to the antiemetic effect.
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