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Clindamycin resistance among Group A Streptococcus isolates in the United States is approximately 1%. Clindamycin is a reasonable drug of choice for treating penicillin-allergic patients 4. Also, clindamycin is very effective for streptococcal pharyngotonsillitis resistant to penicillin 11.
Bactrim is not recommended for preventative or prolonged use in middle ear infections and should not be used in the treatment of streptococcal pharyngitis (strep throat) or certain other strep infections. You should not take Bactrim if you are pregnant or nursing a baby.
Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria
The clinical use of clindamycin is discussed separately in the appropriate topic reviews on specific infections. ... Clindamycin and the related drug lincomycin are often discussed along with the macrolides but are not chemically related. (See "Azithromycin, clarithromycin, and telithromycin".)D
To answer (1), it's probably drugs like vancomycin (and ramiplanin/teicoplanin), linezolid, meropenem/imipenem, and the carbacephems. For (2) it's actually plain-old penicillin (and friends, like the cephalosporins). Actually, ceftriaxone is one of the most lethal antibiotics to susceptible bacteria.
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