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tramadol for depression. Tramadol is a synthetic opiate with seratonin and norepenephrine reuptake blocking properties (kind of like the SSRIs). However, because it is an opiate and thus has a high abuse potential, it is not perscribed to treat depression.
Summary: Since chronic pain syndromes and depression simultaneously occur in many patients, it is likely that tramadol and an SSRI will be used together. However, concomitant use of these drugs is known to increase the risk for seizures and serotonin syndrome (see the figure below).
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